dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

Base Information

Chemical Name:dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate
CAS No.:153886-97-6
Molecular Formula:C₁₆H₁₉O₅P
Molecular Weight:322.298
Hs Code.:

Synonyms:dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

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Chemical Property of dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

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Technology Process of dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

There total 6 articles about dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: [2-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-phosphonic acid dimethyl ester

: 153886-97-6
dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.416667h;
DOI:10.1002/hlca.19930760706

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 153886-97-6
dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / 1H-imidazole / dimethylformamide / 48 h / Ambient temperature

3: 77 percent / LDA / tetrahydrofuran / 1 h / -78 °C

4: 1.) NaH; 2.) MgBr₂ / 1.) THF, 0 deg C, 30 min; 2.) DMF, 15 h, room temp.

5: 85 percent / Bu₄NF / tetrahydrofuran / 0.42 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; magnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19930760706

Reference yield:

: 100-39-0
benzyl bromide

: 153886-97-6
dimethyl 2-(benzyloxy)-5-(hydroxymethyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH; 2.) MgBr₂ / 1.) THF, 0 deg C, 30 min; 2.) DMF, 15 h, room temp.

2: 85 percent / Bu₄NF / tetrahydrofuran / 0.42 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; magnesium bromide; In tetrahydrofuran;
DOI:10.1002/hlca.19930760706