ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

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Chemical Name:ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate
CAS No.:505097-32-5
Molecular Formula:C₂₄H₂₄N₄O₃
Molecular Weight:416.48
Hs Code.:

Synonyms:ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

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Chemical Property of ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

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Technology Process of ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

There total 5 articles about ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 105-36-2
ethyl bromoacetate

: 505097-31-4
3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-1,6-dihydro-6-pyridazinone

: 505097-32-5
ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/S0040-4020(02)01352-2

Reference yield:

: 1632-74-2
3,6-dimethylpyridazine

: 505097-32-5
ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethyl acetate / 12 h / 70 °C

1.2: 85 percent / sodium bicarbonate / ethanol / 12 h / Heating

2.1: 76 percent / AlCl₃ / CH₂Cl₂ / 48 h / 60 °C

3.1: 85 percent / NaOAc; AcOH / 5 h / Heating

4.1: 43 percent / potassium carbonate / dimethylformamide / 48 h / 20 °C

With aluminium trichloride; sodium acetate; potassium carbonate; acetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)01352-2

Reference yield:

: 2632-14-6
4-ethylphenacyl bromide

: 505097-32-5
ethyl 2-(3-[6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazin-7-yl]-6-oxo-1,6-dihydro-1-pyridazinyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethyl acetate / 12 h / 70 °C

1.2: 85 percent / sodium bicarbonate / ethanol / 12 h / Heating

2.1: 76 percent / AlCl₃ / CH₂Cl₂ / 48 h / 60 °C

3.1: 85 percent / NaOAc; AcOH / 5 h / Heating

4.1: 43 percent / potassium carbonate / dimethylformamide / 48 h / 20 °C

With aluminium trichloride; sodium acetate; potassium carbonate; acetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)01352-2