Piperazine, 1-ethyl-3-methyl- (9CI)

Base Information

• Chemical Name: Piperazine, 1-ethyl-3-methyl- (9CI)
• CAS No.: 428871-71-0
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.217
• Mol file: 428871-71-0.mol

Synonyms:1-Ethyl-3-methylpiperazine

Chemical Property of Piperazine, 1-ethyl-3-methyl- (9CI)

Chemical Property:

• PSA: 15.27000
• LogP: 0.56670

Purity/Quality:

99% ^*data from raw suppliers

1-Ethyl-3-methyl-piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazine, 1-ethyl-3-methyl- (9CI)

There total 6 articles about Piperazine, 1-ethyl-3-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-ethylethane-1,2-diamine (110-72-5) + 2-oxopropanal (78-98-8) → 1-ethyl-3-methylpiperazine (428871-71-0)

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride; In aq. phosphate buffer; at 25 ℃; for 4h; pH=7; Enzymatic reaction;

DOI:10.1021/acscatal.8b00291

Reference yield:

(R)-4-Ethyl-2-methyl-1-((R)-1-phenyl-ethyl)-piperazine → (R)-1-ethyl-3-methylpiperazine (321860-21-3,428871-71-0)

Guidance literature:

With hydrogenchloride; palladium dihydroxide; hydrogen; In ethanol; for 18h;

DOI:10.1016/S0040-4039(00)01565-3

Reference yield:

N-ethyl-2-methylallylamine (18328-90-0) → (R)-1-ethyl-3-methylpiperazine (321860-21-3,428871-71-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / Et₃N / ethyl acetate / 1 h / 0 °C

2: 58 percent / OsO₄; NaIO₄ / acetone; H₂O / 3 h / 20 °C

3: 64 percent / AcOH; sodium triacetoxyborohydride; 4A MS / 1,2-dichloro-ethane / 15 h / 0 - 20 °C

4: LiALH₄ / diethyl ether / 0 - 20 °C

5: H₂; Pd(OH)2; HCl / ethanol / 18 h

With hydrogenchloride; palladium dihydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In diethyl ether; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; acetone; 1: Acylation / 2: Oxidation / 3: Cyclization / 4: Reduction / 5: debenzylation;

DOI:10.1016/S0040-4039(00)01565-3

upstream raw materials:

N-ethyl-2-methylallylamine

N-ethyl-N-(2-oxo-propyl)-oxalamic acid methyl ester

(R)-1-Ethyl-5-methyl-4-((R)-1-phenyl-ethyl)-piperazine-2,3-dione

N-ethylethane-1,2-diamine

Refernces

• 1、 Beshore,Dinsmore. "Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization". . p. 8735 - 8739. Retrieved 2007/10/03.