
Tetrahedron Letters p. 8735 - 8739 (2000)
Update date:2022-07-30
Topics:
Beshore
Dinsmore
Herein we report the efficient syntheses of 1,4-disubstituted-2,3-diketopiperazines and 1,4,5-trisubstituted-2,3-diketopiperazines, which feature a tandem reductive amination and acylation. Aliphatic and aromatic primary amines serve as viable nucleophiles under the mild reaction conditions. (C) 2000 Elsevier Science Ltd.
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