110-72-5

Basic information

• Product Name: 2-Aminoethyl(ethyl)amine
• Synonyms: N-Ethyl-1,2-Ethanediamine;N-ETHYLETHYLENEDIAMINE;EAEA;ETHYLAMINO ETHYLAMINE;2-Aminoethyl(ethyl)amine;2-ETHYLAMINOETHYLAMINE;Ethylenediamine, N-ethyl-;n-ethyl-2-ethanediamine
• CAS NO: 110-72-5
• Molecular Formula: C₄H₁₂N₂
• Molecular Weight: 88.15
• EINECS: 203-795-4
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 110-72-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 1.63°C (estimate)
• Boiling Point: 128-130 °C(lit.)
• Flash Point: 50 °F
• Appearance: Clear colorless to slightly brown/Liquid
• Density: 0.837 g/mL at 25 °C(lit.)
• Vapor Pressure: 10.4mmHg at 25°C
• Refractive Index: n20/D 1.439(lit.)
• Storage Temp.: Flammables area
• PKA: pK1:7.63(+2);pK2:10.56(+1) (25°C)
• Water Solubility: Completely soluble in water
• Sensitive: Air Sensitive
• BRN: 1098272
• CAS DataBase Reference: 2-Aminoethyl(ethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminoethyl(ethyl)amine(110-72-5)
• EPA Substance Registry System: 2-Aminoethyl(ethyl)amine(110-72-5)

Safety Data

• Hazard Codes: C,F
• Statements: 10-34-43-11
• Safety Statements: 26-36/37/39-45-25-16
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 3
• F: 10-23
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 110-72-5(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to slightly brown liquid

Uses

N-Ethylethylenediamine is a chelating agent used in mutagenesis research studies. It undergoes condensation with 2-hydroxy-3-methoxybenzaldehyde. It also forms organometallic ruthenium(II) complexes that inhibit the growth in human ovarian cancer cell lines.

General Description

N-Ethylethylenediamine undergoes condensation with 2-hydroxy-3-methoxybenzaldehyde. It also forms organometallic ruthenium(II) complexes that inhibit the growth in human ovarian cancer cell lines.

InChI:InChI=1/C4H12N2/c1-2-6-4-3-5/h6H,2-5H2,1H3/p+2

Upstream product

• 2576-47-8 2-bromoethylamine hydrobromide 
• 75-04-7 ethylamine 
• 74-96-4 ethyl bromide 
• 107-15-3 ethylenediamine 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 151-56-4 ethyleneimine 
• 64-17-5 ethanol 
• 24426-40-2 N-(cyanomethyl)ethylamine 
• 75-00-3 chloroethane 
• 67-56-1 methanol 
• 6274-53-9 N-(2-(phenylsulfonamido)ethyl)acetamide 
• 75-03-6 ethyl iodide 

Downstream Products

• 93638-45-0 N-ethyl-N,N'-ethanediyl-bis-benzamide 
• 113283-93-5 N¹-tert-butoxycarbonyl-N²-ethylethane-1,2-diamine 
• 68084-17-3 α-(2,4-dinitrophenyl)ethyl acetate 
• 107429-65-2 N-[(1-ethyl 2-imidazolin-2-yl)methyl] 2-allyloxy 4-amino 5-chlorobenzamide 
• 6063-67-8 2-butyl-1-ethyl-[1,3,2]diazaborolidine 
• 124-40-3 dimethyl amine 
• 5898-35-1 1-ethyl-2-phenyl-[1,3,2]diazaborolidine 
• 57255-56-8 dichloro(N-ethyl-1,2-ethanediamine)platinum(II) 
• 399566-84-8 (Fe[H₂₅C₁₂OC₆H₄C(O)OC₆H₃(O)CHNCH₂CH₂NHC₂H₅]2)⁽¹⁺⁾*PF₆^(1-)=Fe[H₂₅C₁₂OC₆H₄C(O)OC₆H₃(O)CHNCH₂CH₂NHC₂H₅]2PF₆ 
• 106-64-9 N-ethyl-N,N',N'-trimethylethylenediamine 
• 697216-36-7 N₁-ethyl-N₂-phthalyl-1,2-ethanediamine 
• 1393711-41-5 3-(5,6-dichloro-1-naphthalen-1-ylmethyl-1H-benzimidazol-2-yl)-N-(2-ethylaminoethyl)benzamide 
• 1393711-42-6 3-(1-benzyl-5,6-dichloro-1H-benzimidazol-2-yl)-N-(2-ethylaminoethyl)benzamide 
• 1393711-43-7 3-[5,6-dichloro-1-(4-chlorobenzyl)-1H-benzimidazol-2-yl]-N-(2-ethylaminoethyl)benzamide 

Relevant articles and documents

Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA

While the influence of pKa provided by amine-containing materials in siRNA delivery vectors for use in gene-silencing has been widely studied, there are little reports in which amine pKa is controlled rigorously by using bioisosteres and its effect on gene-silencing. Here, we report that amine pKa could be rigorously controlled by replacement of hydrogen atom(s) with fluorine atom(s). A series of mono- and di-amine lipids with a different number of fluorine atoms were synthesized. The pKa of the polyamine lipids was shifted to a lower value with an increase in the number of fluorine atoms. The optimal pKa for high gene-silencing efficiency varied according to the number of amine residues in the polyamine lipid. Whereas the endosomal escape ability of mono-amine lipid-containing lipid vesicles (LVs) depended on the pKa, that of all tested di-amine lipid-containing LVs showed equal membrane-destabilizing activity. LVs showing moderately weak interactions with siRNA facilitated cytoplasmic release of siRNA, resulting in strong gene-silencing. These findings indicate that appropriate amine pKa engineering depending on the number of amines is important for the induction of effective RNA interference.

HIV INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

N-alkylation of ethylenediamine with alcohols catalyzed by CuO-NiO/γ-Al2O3

A simple method for N-alkylation of 1, 2-diaminoethane with different alcohols in a fixed-bed reactor using cheap CuO-NiO/γ-Al2O 3 as the catalyst has been developed. The present catalytic system was applicable in the N-alkylation of 1, 2-diaminoethane with both primary and secondary alcohols. Mono-N-alkylation of 1, 2-diaminoethane with low-carbon alcohols resulted in high yields; the yields of tetra-N-alkylation of 1, 2-diaminoethane with low-carbon alcohols declined markedly with the increase of the molecular volume of alcohols.