(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

Base Information

• Chemical Name: (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile
• CAS No.: 861718-83-4
• Molecular Formula: C₁₂H₁₄ClF₂NOSi
• Molecular Weight: 289.785
• Mol file: 861718-83-4.mol

Synonyms:(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

Chemical Property of (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

There total 2 articles about (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) → (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile (861718-83-4) + (R)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

Guidance literature:

With tris[N,N-bis(trimethylsilyl)amide]gadolinium(III); (2S,3S,4R)-2-Ph₂P(O)CH₂-3-OH-4-(2-OH-4,5-F₂-C₆H₂)tetraHpyran; propiononitrile; at -40 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.1021/ol050398+

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) + propiononitrile (107-12-0) → (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile (861718-83-4) + (R)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

Guidance literature:

trimethylsilyl cyanide; propiononitrile; With tris[N,N-bis(trimethylsilyl)amide]gadolinium(III); 1,5-anhydro-2,6-dideoxy-3-O-(4,5-difluoro-2-hydroxyphenyl)-6-(diphenylphosphinyl)-D-arabino-hexitol; at -30 ℃; for 0.333333h; Inert atmosphere;

2-chloro-1-(2,4-dichlorophenyl)ethanone; at -30 ℃; for 3h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo4019528

Reference yield: 87.0%

(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile (861718-83-4) → 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde (861718-85-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 - -40 ℃; for 2h;

DOI:10.1021/ol050398+

upstream raw materials:

trimethylsilyl cyanide

2-chloro-1-(2,4-dichlorophenyl)ethanone

propiononitrile

Downstream raw materials:

3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde

3-chloro-2-(2,4-difluorophenyl)-2-hydroxypropionaldehyde

(R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol

(S)-3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol