4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine

Base Information

• Chemical Name: 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine
• CAS No.: 1450754-60-5
• Molecular Formula: C₂₇H₂₂FN₅O
• Molecular Weight: 451.503
• Mol file: 1450754-60-5.mol

Synonyms:4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine

Chemical Property of 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine

There total 12 articles about 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

C20H14FN3O2 + 3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine (1450754-38-7) → 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine (1450754-60-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201300683

Reference yield:

1-(4-fluorophenyl)-2-(4-pyridyl)ethanone (6576-05-2) → 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine (1450754-60-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / Inert atmosphere

2.1: ammonium acetate; acetic acid / Inert atmosphere

3.1: triethyl phosphite / N,N-dimethyl-formamide / Inert atmosphere

3.2: Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; potassium carbonate; acetic acid; sodium nitrite; triethyl phosphite; In water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201300683

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → 4-(2-(4-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)phenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)pyridine (1450754-60-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 12 h / Inert atmosphere

2.1: lithium diisopropyl amide / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / Inert atmosphere

4.1: ammonium acetate; acetic acid / Inert atmosphere

5.1: triethyl phosphite / N,N-dimethyl-formamide / Inert atmosphere

5.2: Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; potassium carbonate; acetic acid; lithium diisopropyl amide; sodium nitrite; triethyl phosphite; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201300683

upstream raw materials:

1-hydroxy-3-ketohept-6-yne

2-(3-(but-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-ol

4-Fluorobenzoic acid

4-fluorobenzoyl chloride