Benzenemethanol, 5-fluoro-2-methoxy- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 5-fluoro-2-methoxy- (9CI)
• CAS No.: 426831-32-5
• Molecular Formula: C8H9 F O2
• Molecular Weight: 156.157
• Hs Code.: 2909499000
• Mol file: 426831-32-5.mol

Synonyms:(5-Fluoro-2-methoxyphenyl)methanol;5-Fluoro-2-methoxybenzyl alcohol

Chemical Property of Benzenemethanol, 5-fluoro-2-methoxy- (9CI)

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 242℃
• Flash Point: 119℃
• PSA: 29.46000
• Density: 1.187
• LogP: 1.32660
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Fluoro-2-methoxybenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 5-fluoro-2-methoxy- (9CI)

There total 6 articles about Benzenemethanol, 5-fluoro-2-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

5-fluoro-2-methoxybenzaldehyde (19415-51-1) → (5-fluoro-2-methoxyphenyl)methanol (426831-32-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 4h;

Reference yield:

4-morpholinecarboxaldehyde (4394-85-8) + 2-bromo-4-fluoro-1-methoxybenzene (452-08-4) → (5-fluoro-2-methoxyphenyl)methanol (426831-32-5) + 4-(5-fluoro-2-methoxybenzyl)morpholine (1441770-44-0)

Guidance literature:

2-bromo-4-fluoro-1-methoxybenzene; With diisobutylaluminium hydride; magnesium; In tetrahydrofuran; Inert atmosphere;

4-morpholinecarboxaldehyde; In tetrahydrofuran; Inert atmosphere;

With lithium borohydride; In tetrahydrofuran; at 23 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo400647t

Reference yield:

N-Formylpiperidine (2591-86-8) + 2-bromo-4-fluoro-1-methoxybenzene (452-08-4) → (5-fluoro-2-methoxyphenyl)methanol (426831-32-5) + 1-(5-fluoro-2-methoxybenzyl)piperidine (1441770-51-9)

Guidance literature:

2-bromo-4-fluoro-1-methoxybenzene; With diisobutylaluminium hydride; magnesium; In tetrahydrofuran; Inert atmosphere;

N-Formylpiperidine; In tetrahydrofuran; Inert atmosphere;

With lithium borohydride; In tetrahydrofuran; at 23 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo400647t

upstream raw materials:

5-fluoro-2-methoxybenzaldehyde

2-bromo-4-fluoro-1-methoxybenzene

N,N-dimethyl-formamide

4-morpholinecarboxaldehyde

Downstream raw materials:

2-(bromomethyl)-4-fluoro-1-methoxybenzene

2-hydroxy-5-fluorophenyl-acetonitrile

C₇H₆BrFO

C₁₅H₁₂FNO

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