(2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide
CAS No.:1584714-28-2
Molecular Formula:C₂₆H₂₆F₃N₅O₃
Molecular Weight:513.519
Hs Code.:

Synonyms:(2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

There total 8 articles about (2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1584715-56-9
(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

: 1584714-28-2
(2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 1584715-50-3
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584714-28-2
(2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

2: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonium chloride / N,N-dimethyl-formamide

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; ammonium chloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1584715-52-5
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584714-28-2
(2R,3S)-N-((3S)-9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-propyl-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonium chloride / N,N-dimethyl-formamide

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;