(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate
CAS No.:1584715-52-5
Molecular Formula:C₃₅H₄₇BrF₃N₃O₅Si
Molecular Weight:754.76
Hs Code.:

(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Synonyms:(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

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Chemical Property of (2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

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Technology Process of (2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

There total 5 articles about (2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

: 1584715-50-3
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1584715-52-5
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1584715-52-5
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 1 h

2.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

4.1: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1581734-65-7
(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hexanoic acid

: 1584715-52-5
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

2: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

With tetra-(n-butyl)ammonium iodide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide;