(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate
CAS No.:1584715-54-7
Molecular Formula:C₃₆H₄₇F₃N₄O₅Si
Molecular Weight:700.874
Hs Code.:

(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Synonyms:(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

There total 6 articles about (2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.6%

: 557-21-1
zinc(II) cyanide

: 1584715-52-5
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584715-54-7
(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 100 ℃; Inert atmosphere;

Reference yield:

: 1584715-50-3
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584715-54-7
(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

2: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; caesium carbonate; zinc; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1584715-54-7
(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 1 h

2.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

4.1: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

5.1: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; zinc; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;