(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

Base Information

Chemical Name:(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid
CAS No.:1584715-56-9
Molecular Formula:C₂₆H₂₅F₃N₄O₄
Molecular Weight:514.504
Hs Code.:

Synonyms:(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

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Chemical Property of (2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

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Technology Process of (2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

There total 7 articles about (2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1584715-54-7
(2S,3R)-tert-butyl 3-((9-cyano-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584715-56-9
(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h; Inert atmosphere;

Reference yield:

: 1584715-50-3
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584715-56-9
(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

2: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; caesium carbonate; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1584715-52-5
(2S,3R)-tert-butyl 3-((9-bromo-2-oxo-5-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoate

: 1584715-56-9
(2S,3R)-3-((9-cyano-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-propylhexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; trifluoroacetic acid; zinc; In dichloromethane; N,N-dimethyl acetamide;