3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine

Base Information

Chemical Name:3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine
CAS No.:425378-79-6
Molecular Formula:C17H19 B F N O2
Molecular Weight:299.153
Hs Code.:
DSSTox Substance ID:DTXSID60465570
Wikidata:Q82291618
Mol file:425378-79-6.mol

Synonyms:425378-79-6;3-(2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)PYRIDINE;3-[2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridine;3-(2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl)pyridine;3-[2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyridine;starbld0000234;SCHEMBL2649267;DTXSID60465570;YKXKGLXAERYSJN-UHFFFAOYSA-N

Suppliers and Price of 3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)PYRIDINE 95.00%
5MG
$ 501.28

Total 3 raw suppliers

Chemical Property of 3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine

Chemical Property:

PSA：31.35000
LogP:3.18690
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:299.1492872
Heavy Atom Count:22
Complexity:388

Purity/Quality:

97% ^*data from raw suppliers

3-(2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C=C2)F)C3=CN=CC=C3

Technology Process of 3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine

There total 7 articles about 3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 425378-78-5
3-(5-bromo-2-fluorophenyl)pyridine

: 73183-34-3
bis(pinacol)diborane

: 425378-79-6
3-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyridine

Guidance literature:: With sodium hydroxide; potassium acetate; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 628691-75-8
3-(2-fluoro-5-nitrophenyl)pyridine

: 425378-79-6
3-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: SnCl₂*2H₂O / ethanol

2.1: NaNO₂; aq. HBr; CuBr / 0 - 50 °C

2.2: Pd(dppf)Cl₂; KOAc / dioxane / 90 °C

With hydrogen bromide; tin(ll) chloride; copper(I) bromide; sodium nitrite; In ethanol;
DOI:10.1016/j.bmcl.2005.12.044

Reference yield:

: 425378-68-3
2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 425378-79-6
3-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd₂(dba)3; P(t-Bu)3; KF / tetrahydrofuran / 0 - 50 °C

2.1: SnCl₂*2H₂O / ethanol

3.1: NaNO₂; aq. HBr; CuBr / 0 - 50 °C

3.2: Pd(dppf)Cl₂; KOAc / dioxane / 90 °C

With potassium fluoride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tri-tert-butyl phosphine; hydrogen bromide; tin(ll) chloride; copper(I) bromide; sodium nitrite; In tetrahydrofuran; ethanol; 1.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.12.044