Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Base Information

Chemical Name:Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester
CAS No.:193416-64-7
Molecular Formula:C₄₄H₆₂O₁₀SSi
Molecular Weight:811.122
Hs Code.:

Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Synonyms:Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Suppliers and Price of Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

There total 11 articles about Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 193416-51-2
Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-7-(4-methoxy-benzyloxy)-3-methylene-5-triethylsilanyloxy-heptyl ester

: 193416-64-7
Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Guidance literature:: With tetrabutyl ammonium fluoride;
DOI:10.1021/jo9708755

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 193416-64-7
Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / Et₃N

2: 97 percent / DDQ / CH₂Cl₂

3: 80 percent

4: CrCl₂/NiCl₂ / tetrahydrofuran

5: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

6: 96 percent / Et₃N / CH₂Cl₂

7: 94 percent / TBAF

With chromium dichloride; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9708755

Reference yield:

: {2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-[2-(4-methoxy-benzyloxy)-ethyl]-3,6-dihydro-2H-pyran-4-yloxy}-triethyl-silane

: 193416-64-7
Methanesulfonic acid (1S,5R)-1-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-ylmethyl]-5-hydroxy-7-(4-methoxy-benzyloxy)-3-methylene-heptyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: TBAF, TsOH / tetrahydrofuran

2: 97 percent / K(s-Bu₃BH) / tetrahydrofuran

3: 93 percent / Et₃N

4: 97 percent / DDQ / CH₂Cl₂

5: 80 percent

6: CrCl₂/NiCl₂ / tetrahydrofuran

7: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

8: 96 percent / Et₃N / CH₂Cl₂

9: 94 percent / TBAF

With chromium dichloride; tetrabutyl ammonium fluoride; potassium tri-sec-butyl-borohydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9708755