2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

Base Information

Chemical Name:2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate
CAS No.:1128046-34-3
Molecular Formula:C₁₈H₂₁N₃O₃
Molecular Weight:327.383
Hs Code.:

Synonyms:2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

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Chemical Property of 2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

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Technology Process of 2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

There total 5 articles about 2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 29071-09-8
2-acetoxy-2-phenylacetic acid

: 866751-49-7
1‐(3,5,6‐trimethylpyrazin‐2‐yl)methanamine

: 1128046-34-3
2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

Guidance literature:: 2-acetoxy-2-phenylacetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 5h;

1‐(3,5,6‐trimethylpyrazin‐2‐yl)methanamine; In tetrahydrofuran; at 20 ℃;
DOI:10.2174/157340641130900042

Reference yield:

: 75907-74-3
2-Pyrazinemethanol,3,5,6-trimethyl

: 1128046-34-3
2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 2.5 h / 0 - 20 °C

2.1: ethanol; N,N-dimethyl-formamide / 1.5 h / 80 °C

2.2: 2.5 h / Reflux

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 5 h / 0 °C

3.2: 20 °C

With thionyl chloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 2.2: |Gabriel Amine Synthesis;
DOI:10.2174/157340641130900042

Reference yield:

: 22978-83-2
2,3,5,6-tetramethylpyrazine mono N-oxide

: 1128046-34-3
2-oxo-1-phenyl-2-((3,5,6-trimethylpyrazin-2-yl)methylamino)ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride

2.1: thionyl chloride / dichloromethane / 2.5 h / 0 - 20 °C

3.1: ethanol; N,N-dimethyl-formamide / 1.5 h / 80 °C

3.2: 2.5 h / Reflux

4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 5 h / 0 °C

4.2: 20 °C

With thionyl chloride; acetic anhydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.2: |Gabriel Amine Synthesis;
DOI:10.2174/157340641130900042