(S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide

Base Information

• Chemical Name: (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide
• CAS No.: 713124-87-9
• Molecular Formula: C₂₇H₃₄N₄O₂S
• Molecular Weight: 478.659
• Mol file: 713124-87-9.mol

Synonyms:(S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide

Chemical Property of (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide

There total 7 articles about (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-D-Phe (2448-45-5) → (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide (713124-87-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 97.5 percent / sodium hydride / tetrahydrofuran / 22 h / 0 - 20 °C

2: 98 percent / triethylamine; diethyl phosphorocyanidate / CH₂Cl₂ / 0.33 h / 0 °C

3: HBr; acetic acid / 1 h / 20 °C

4: 58 percent / diisopropylethylamine; PyBroP / CH₂Cl₂ / 4 h / 0 °C

5: tris(2-aminoethyl)amine / CH₂Cl₂ / 1.5 h / 20 °C

With 2,2',2''-triaminotriethylamine; diethyl cyanophosphonate; hydrogen bromide; sodium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo030358o

Reference yield:

((S)-3-Methyl-1-{methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamoyl}-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (713124-85-7) → (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide (713124-87-9)

Guidance literature:

With 2,2',2''-triaminotriethylamine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1021/jo030358o

Reference yield:

Fmoc-Leu-OH (35661-60-0) → (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide (713124-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / diisopropylethylamine; PyBroP / CH₂Cl₂ / 4 h / 0 °C

2: tris(2-aminoethyl)amine / CH₂Cl₂ / 1.5 h / 20 °C

With 2,2',2''-triaminotriethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane;

DOI:10.1021/jo030358o

upstream raw materials:

((S)-3-Methyl-1-{methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamoyl}-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Fmoc-Leu-OH

Cbz-D-Phe

(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine