N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

Base Information

• Chemical Name: N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide
• CAS No.: 145942-97-8
• Molecular Formula: C₁₄H₁₈F₂N₄OS
• Molecular Weight: 328.386

Synonyms:N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

Chemical Property of N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

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Technology Process of N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

There total 2 articles about N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl> disulfide (136598-92-0) → N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide (145942-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₂ / CH₂Cl₂; CCl₄ / 0.33 h / 0 °C

2: CH₂Cl₂; CCl₄; toluene / 0.5 h / 0 °C

With chlorine; In tetrachloromethane; dichloromethane; toluene;

DOI:10.1248/cpb.42.85

Reference yield:

dimethyl amine (124-40-3) + C12H12ClF2N3OS (1026878-17-0) → N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide (145942-97-8)

Guidance literature:

In tetrachloromethane; dichloromethane; toluene; at 0 ℃; for 0.5h;

DOI:10.1248/cpb.42.85

Reference yield:

N,N-dimethyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide (145942-97-8) → (2R,3R)-3-(2,4-difluorophenyl)-N,N-dimethyl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butanesulfonamide

Guidance literature:

With potassium permanganate; In acetone; Yield given; Ambient temperature;

DOI:10.1248/cpb.42.85

upstream raw materials:

dimethyl amine

C₁₂H₁₂ClF₂N₃OS

bis<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl> disulfide

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