1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

Base Information

Chemical Name:1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one
CAS No.:1264940-58-0
Molecular Formula:C₂₆H₃₃N₇O₂
Molecular Weight:475.594
Hs Code.:

Synonyms:1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

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Chemical Property of 1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

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Technology Process of 1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

There total 6 articles about 1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1264940-56-8
1-methyl-2-[1-(4-piperazin-1-ylmethyl-phenyl)piperidin-4-yloxy]-1H-[4,4']bipyrimidinyl-6-one

: 1264940-58-0
1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In water; 1,2-dichloro-ethane; at 20 ℃; for 2h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1264940-58-0
1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C

5: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene; mineral oil;

Reference yield:

: 1264943-62-5
C₁₉H₂₅N₅O₄

: 1264940-58-0
1-methyl-2-{1-[4-(4-methyl-piperazin-1-ylmethyl)phenyl]piperidin-4-yloxy}-1H-[4,4']bipyrimidinyl-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 20 °C

4: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos; In dichloromethane; water; 1,2-dichloro-ethane; toluene;