4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

Base Information

Chemical Name:4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester
CAS No.:1370257-50-3
Molecular Formula:C₁₉H₁₃Cl₃F₃NO₂
Molecular Weight:450.672
Hs Code.:

Synonyms:4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

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Chemical Property of 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

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Technology Process of 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

There total 5 articles about 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1370257-49-0
5-(4-bromo-3-chloro-phenyl)-3-(3,5-dichloro-phenyl)-3-trifluoromethyl-3,4-dihydro-2H-pyrrole

: 1370257-50-3
4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

Guidance literature:: With sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 16h; under 3750.38 Torr; Autoclave;

Reference yield:

: 25118-59-6
4-bromo-3-chlorobenzoic acid

: 1370257-50-3
4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: Lawessons reagent / toluene / 1 h / Reflux

3.1: caesium carbonate / tetrahydrofuran / -5 - 40 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -7 - 20 °C

5.1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 80 °C / 3750.38 Torr / Autoclave

With Lawessons reagent; dmap; tetrabutyl ammonium fluoride; sodium acetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1370257-46-7
4-bromo-3-chloro-N-trimethylsilanylmethyl-benzamide

: 1370257-50-3
4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / toluene / 1 h / Reflux

2: caesium carbonate / tetrahydrofuran / -5 - 40 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / -7 - 20 °C

4: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 80 °C / 3750.38 Torr / Autoclave

With Lawessons reagent; tetrabutyl ammonium fluoride; sodium acetate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;