N-(Cyclohexylcarbonyl)-N-(2,2-dimethoxyethyl)glycine

Base Information

Chemical Name:N-(Cyclohexylcarbonyl)-N-(2,2-dimethoxyethyl)glycine
CAS No.:60744-45-8
Molecular Formula:C₁₃H₂₃NO₅
Molecular Weight:273.329
Hs Code.:
DSSTox Substance ID:DTXSID501220557

Synonyms:DTXSID501220557;60744-45-8;N-(Cyclohexylcarbonyl)-N-(2,2-dimethoxyethyl)glycine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(Cyclohexylcarbonyl)-N-(2,2-dimethoxyethyl)glycine

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:273.15762283
Heavy Atom Count:19
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(CN(CC(=O)O)C(=O)C1CCCCC1)OC

Technology Process of N-(Cyclohexylcarbonyl)-N-(2,2-dimethoxyethyl)glycine

There total 3 articles about N-(Cyclohexylcarbonyl)-N-(2,2-dimethoxyethyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 406954-87-8
phenylmethyl 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetate

: 60744-45-8
2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jo010990m

Reference yield:

: 98265-88-4
phenylmethyl 2-[(2,2-dimethoxyethyl)amino]acetate

: 60744-45-8
2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH₂Cl₂ / 16 h / 20 °C

2: 98 percent / H₂ / Pd/C / aq. ethanol

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo010990m

Reference yield:

: 98-89-5
Cyclohexanecarboxylic acid

: 60744-45-8
2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH₂Cl₂ / 16 h / 20 °C

2: 98 percent / H₂ / Pd/C / aq. ethanol

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo010990m