N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

Base Information

Chemical Name:N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide
CAS No.:406954-88-9
Molecular Formula:C₂₁H₃₁BrN₂O₄
Molecular Weight:455.392
Hs Code.:

Synonyms:N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

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Chemical Property of N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

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Technology Process of N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

There total 7 articles about N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 2-(2-bromophenyl)ethylisocyanide

: 22483-09-6
2,2-dimethoxyethylamine

: 98-89-5
Cyclohexanecarboxylic acid

: 406954-88-9
N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

Guidance literature:: In methanol; at 0 - 20 ℃; for 48h;
DOI:10.1111/cbdd.12153

Reference yield: 68.0%

: 65185-58-2
2-(2-bromophenyl)ethanamine

: 60744-45-8
2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid

: 406954-88-9
N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jo010990m

Reference yield:

: 98265-88-4
phenylmethyl 2-[(2,2-dimethoxyethyl)amino]acetate

: 406954-88-9
N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH₂Cl₂ / 16 h / 20 °C

2: 98 percent / H₂ / Pd/C / aq. ethanol

3: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; DMAP / CH₂Cl₂ / 16 h / 20 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo010990m