1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

Base Information

Chemical Name:1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone
CAS No.:1382996-68-0
Molecular Formula:C₁₆H₂₂BClO₄
Molecular Weight:324.612
Hs Code.:

Synonyms:1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

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Chemical Property of 1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

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Technology Process of 1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

There total 3 articles about 1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1382995-35-8
1-(5-chloro-3-iodo-2-methoxy-4-methylphenyl)ethan-1-one

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1382996-68-0
1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

Guidance literature:: With triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382996-68-0
1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetic acid / 18 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: triethylamine / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With N-iodo-succinimide; potassium carbonate; triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; acetic acid; acetone;

Reference yield:

: 292144-86-6
1-(5-chloro-2-hydroxy-3-iodo-4-methylphenyl)ethan-1-one

: 1382996-68-0
1-[5-chloro-2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: triethylamine / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With potassium carbonate; triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; acetone;