Technology Process of N-[2-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-benzo[b]thiophen-7-yl]-6-chloronicotinamide
There total 7 articles about N-[2-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-benzo[b]thiophen-7-yl]-6-chloronicotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-[(6-chloro-pyridine-3-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid;
With
benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Further stages.;
DOI:10.1021/jm070415w
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 98 percent / H2 / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr
2.1: triethylamine; BOPCl / CH2Cl2 / 0.25 h / 20 °C
2.2: 68 percent / CH2Cl2 / 12 h / 20 °C
3.1: 100 percent / aq. NaOH / tetrahydrofuran; methanol / 12 h / 20 °C
4.1: HOBt; EDC / dimethylformamide / 0.25 h / 20 °C
4.2: 41 percent / dimethylformamide / 12 h / 20 °C
With
sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm070415w
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 94 percent / K2CO3 / dimethylformamide / 12 h / 0 - 20 °C
2.1: 98 percent / H2 / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr
3.1: triethylamine; BOPCl / CH2Cl2 / 0.25 h / 20 °C
3.2: 68 percent / CH2Cl2 / 12 h / 20 °C
4.1: 100 percent / aq. NaOH / tetrahydrofuran; methanol / 12 h / 20 °C
5.1: HOBt; EDC / dimethylformamide / 0.25 h / 20 °C
5.2: 41 percent / dimethylformamide / 12 h / 20 °C
With
sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm070415w
![7-[(6-chloro-pyridine-3-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid](/Databaselist/images/loading.webp)
