methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate
CAS No.:1596341-59-1
Molecular Formula:C₂₇H₃₂F₃NO₃
Molecular Weight:475.551
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

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Technology Process of methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

There total 13 articles about methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1596341-58-0
methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-[(trifluoromethane)sulfonyloxy]-6-(trifluoromethyl) phenyl]acetate

: 181219-01-2
4-pyridineboronic acid pinacol ester

: 1596341-59-1
methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 85 ℃; Inert atmosphere;

Reference yield:

: 1596341-55-7
methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

: 1596341-59-1
methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: perchloric acid / water / 1 h / 0 °C

2: hydrogen; palladium on activated charcoal / ethyl acetate / 48 h

3: triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596341-59-1
methyl 2-(tert-butoxy)-2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-(pyridin-4-yl)-6-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 65 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

7.1: sodium tetrahydroborate / diethylene glycol dimethyl ether / 1 h / 0 °C

8.1: perchloric acid / water / 1 h / 0 °C

9.1: hydrogen; palladium on activated charcoal / ethyl acetate / 48 h

10.1: triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; perchloric acid; palladium on activated charcoal; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; diethylene glycol dimethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;