methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate
CAS No.:1596341-55-7
Molecular Formula:C₂₅H₂₇F₃O₄
Molecular Weight:448.482
Hs Code.:

Synonyms:methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Chemical Property of methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Technology Process of methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

There total 10 articles about methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: C₂₅H₂₅F₃O₄

: 1596341-55-7
methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: With sodium tetrahydroborate; In 1,2-dimethoxyethane; at 0 ℃; for 1h;

Reference yield:

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1596341-55-7
methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 65 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

3: N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4: sodium tetrahydroborate / diethylene glycol dimethyl ether / 1 h / 0 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596341-55-7
methyl 2-[3-(benzyloxy)-2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 65 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

7.1: sodium tetrahydroborate / diethylene glycol dimethyl ether / 1 h / 0 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; mineral oil;