ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Base Information

Chemical Name:ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate
CAS No.:1596341-54-6
Molecular Formula:C₁₉H₂₀F₄O₃
Molecular Weight:372.36
Hs Code.:

Synonyms:ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Chemical Property of ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Technology Process of ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

There total 5 articles about ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 859217-67-7
2-(4,4-dimethylcyclohex-1-ene-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1596341-54-6
ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 65 ℃; for 2h; Inert atmosphere;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596341-54-6
ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; water;

Reference yield:

: 1403382-20-6
ethyl 2-[3-fluoro-2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-54-6
ethyl 2-[2-(4,4-dimethylcyclohex-1-en-1-yl)-3-fluoro-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

2: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;