(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Base Information

Chemical Name:(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide
CAS No.:1443008-05-6
Molecular Formula:C₁₈H₂₂N₂O₂
Molecular Weight:298.385
Hs Code.:

Synonyms:(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

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Technology Process of (R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

There total 18 articles about (R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1443008-03-4
tert-butyl ((R)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

: 1443008-05-6
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 23 ℃; for 2.11667h; Inert atmosphere;
DOI:10.1021/ol401337p

Reference yield:

: 550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4
(1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol

: 1443008-05-6
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 0 - 23 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 2.12 h / 0 - 23 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ol401337p

Reference yield:

: 1443008-04-5
tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

: 1443008-05-6
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.62 h / 0 - 23 °C / Inert atmosphere

2.1: benzene / 0.5 h / 23 °C / 200 Torr / Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 - 0 °C / Inert atmosphere

3.2: 3.5 h / -50 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 23 °C / Inert atmosphere

5.1: water / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 12 h / 0 - 23 °C / Inert atmosphere

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2.12 h / 0 - 23 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/ol401337p