(R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:(R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate
CAS No.:1304668-78-7
Molecular Formula:C₁₉H₂₇BrN₂O₅
Molecular Weight:443.338
Hs Code.:

Synonyms:(R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

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Technology Process of (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

There total 3 articles about (R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 40460-91-1
2-(4-bromophenyl)propanal

: 1304668-78-7
(R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: With (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid; In tetrahydrofuran; at 0 ℃; for 48h; enantioselective reaction;
DOI:10.1016/j.tet.2013.04.103

Reference yield:

: 80909-78-0
p-bromo-α-methylstyrene oxide

: 1304668-78-7
(R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere

2: (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid / tetrahydrofuran / 48 h / 0 °C

With boron trifluoride diethyl etherate; (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid; In tetrahydrofuran;
DOI:10.1016/j.tet.2013.04.103

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1304668-78-7
(R)-di-tert-butyl 1-(2-(4-bromophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 70 °C / Inert atmosphere

1.2: 48 h / Inert atmosphere

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere

3.1: (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid / tetrahydrofuran / 48 h / 0 °C

With boron trifluoride diethyl etherate; sodium hydride; (S)-4-(tert-butoxy)-2-methyl-4-oxobutanoic acid; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.tet.2013.04.103