2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

Base Information

Chemical Name:2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane
CAS No.:74075-27-7
Molecular Formula:C₂₄H₂₅NO₆
Molecular Weight:423.466
Hs Code.:

Synonyms:2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

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Chemical Property of 2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

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Technology Process of 2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

There total 2 articles about 2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 107-21-1
ethylene glycol

: 74075-26-6
2-(3-oxo-5-phenyl-(4S)-4-phthalimidopentyl)-1,3-dioxolane

: 74075-27-7
2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

Guidance literature:: With p-toluenesulfonyl chloride; In toluene; for 11h;
DOI:10.1021/jm00186a020

Reference yield:

: 33861-65-3
N-phthaloyl-L-phenylalanine-2-mercaptopyridyl thioester

: 74075-27-7
2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) magnesium / 1.) THF, from 30 deg C to 35 deg C, 1 h, 2.) THF, RT, 20 h

2: 58 percent / p-toluenesulfonyl chloride / toluene / 11 h

With magnesium; p-toluenesulfonyl chloride; In toluene;
DOI:10.1021/jm00186a020

Reference yield:

: 74075-27-7
2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<(1S)-1-phthalimido-2-phenylethyl>-1,3-dioxolane

: 74075-33-5
SRI-20

Guidance literature:: Multi-step reaction with 6 steps

1: 1.3 g / hydrazine / ethanol / 0.25 h / Heating

2: 72.9 percent / pyridine / 72 h / Ambient temperature

3: 59 percent / CrO₃, 35percent H₂SO₄ / acetone / 1 h / Ambient temperature

4: trifluoroacetic acid; H₂O / 16 h / Ambient temperature

5: 71 percent / 1-hydroxybenzotriazole hydrate, triethylamine, dicyclohexylcarbodiimide / CH₂Cl₂ / 72 h / Ambient temperature

6: 71.8 percent / H₂ / 10percent Pd/C / acetic acid / 15 h / 760 Torr

With chromium(VI) oxide; sulfuric acid; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; hydrazine; palladium on activated charcoal; In pyridine; ethanol; dichloromethane; water; acetic acid; acetone; trifluoroacetic acid;
DOI:10.1021/jm00186a020