2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

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Chemical Name:2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine
CAS No.:1443732-65-7
Molecular Formula:C₂₁H₁₃ClF₄N₂
Molecular Weight:404.794
Hs Code.:

Synonyms:2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

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Chemical Property of 2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

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Technology Process of 2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

There total 4 articles about 2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.4%

: 957034-45-6
(2-methyl-4-(trifluoromethyl)phenyl)boronic acid

: 1443732-80-6
5-bromo-2-(2-chloro-6-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

: 1443732-65-7
2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1443732-78-2
2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol

: 1443732-65-7
2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2.25 h / 0 °C

2: iron / acetic acid / 2.25 h

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iron; potassium carbonate; Dess-Martin periodane; In 1,4-dioxane; dichloromethane; water; acetic acid; 3: |Suzuki Coupling;

Reference yield:

: 22282-96-8
6-bromo-2-methyl-3-nitro-pyridine

: 1443732-65-7
2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / diethyl ether / 1 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 2.25 h / 0 °C

3: iron / acetic acid / 2.25 h

4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium ethanolate; iron; potassium carbonate; Dess-Martin periodane; In 1,4-dioxane; diethyl ether; dichloromethane; water; acetic acid; 4: |Suzuki Coupling;