2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol

Base Information

• Chemical Name: 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol
• CAS No.: 1443732-78-2
• Molecular Formula: C₁₃H₉BrClFN₂O₃
• Molecular Weight: 375.581
• Mol file: 1443732-78-2.mol

Synonyms:2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol

Chemical Property of 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol

There total 1 articles about 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

6-bromo-2-methyl-3-nitro-pyridine (22282-96-8) + ethanol (64-17-5) + 2-chloro-6-fluorobenzaldehyde (387-45-1) → 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol (1443732-78-2) + 1-(2-chloro-6-fluorophenyl)-2-(6-ethoxy-3-nitropyridin-2-yl)ethanol

Guidance literature:

With sodium ethanolate; In diethyl ether; at 0 ℃; for 1h;

Reference yield: 76.0%

2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol (1443732-78-2) → 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanone (1443732-79-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 2.25h;

Reference yield:

2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanol (1443732-78-2) → 2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine (1443732-65-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2.25 h / 0 °C

2: iron / acetic acid / 2.25 h

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iron; potassium carbonate; Dess-Martin periodane; In 1,4-dioxane; dichloromethane; water; acetic acid; 3: |Suzuki Coupling;

upstream raw materials:

6-bromo-2-methyl-3-nitro-pyridine

ethanol

2-chloro-6-fluorobenzaldehyde

Downstream raw materials:

5-bromo-2-(2-chloro-6-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine

2-(2-chloro-6-fluorophenyl)-5-(2-methyl-4-(trifluoromethyl)phenyl)-1H-pyrrolo[3,2-b]pyridine

2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanone