N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

Base Information

Chemical Name:N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine
CAS No.:86176-98-9
Molecular Formula:C₁₃H₉F₆N₅O
Molecular Weight:365.238
Hs Code.:

Synonyms:N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

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Technology Process of N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

There total 2 articles about N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 18960-29-7
1-carbamimidamido-N-[4-(trifluoromethyl)phenyl]methanimidamidehydrochloride

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 86176-98-9
N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

Guidance literature:: With sodium hydroxide; In ethanol; water; for 48h; Ambient temperature;
DOI:10.1021/jm00363a010

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 86176-98-9
N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / conc. HCl / propan-2-ol / 26 h / Heating

2: 36 percent / 50percent aq. NaOH / H₂O; ethanol / 48 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm00363a010

Reference yield:

: 6297-14-9
4-amino-α-diethylamino-o-cresol dihydrochloride

: 86176-98-9
N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine

: 86177-26-6
N-[4-(3-Diethylaminomethyl-4-hydroxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-trifluoromethyl-phenyl)-guanidine

Guidance literature:: With trichlorophosphate; Yield given. Multistep reaction; 1.) reflux, 2 h, 2.) ethanol, reflux, 40 h;
DOI:10.1021/jm00363a010