tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

Base Information

Chemical Name:tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate
CAS No.:1380671-51-1
Molecular Formula:C₁₅H₁₈ClNO₅
Molecular Weight:327.765
Hs Code.:

Synonyms:tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

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Chemical Property of tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

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Technology Process of tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

There total 1 articles about tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.6%

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 1380671-51-1
tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

Guidance literature:: tert-butyl cyclopropanecarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

4-chloro-3-nitro-benzaldehyde; In tetrahydrofuran; hexane; at 20 ℃;

With ammonium chloride; In tetrahydrofuran; hexane; water;

Reference yield: 80.0%

: 1380671-51-1
tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

: 1380671-54-4
tert-Butyl 1-[(3-amino-4-chlorophenyl)(hydroxy)methyl]cyclopropanecarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 72h; under 760.051 Torr;

Reference yield:

: 1380671-51-1
tert-Butyl 1-[(4-chloro-3-nitrophenyl)(hydroxy)methyl]cyclopropanecarboxylate

: 1380671-58-8
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 760.05 Torr

2: pyridine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

With pyridine; hydrogen; HATU; palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide;