(E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde

Base Information

• Chemical Name: (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde
• CAS No.: 114651-98-8
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.339
• Mol file: 114651-98-8.mol

Synonyms:(E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde

Chemical Property of (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde

There total 7 articles about (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(Z)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylonitrile (37629-77-9) → (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde (114651-98-8)

Guidance literature:

(Z)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylonitrile; With diisobutylaluminium hydride; In dichloromethane; cyclohexane; at -78 - 20 ℃; for 3.5h;

With hydrogenchloride; In dichloromethane; cyclohexane; water; for 0.5h;

DOI:10.1021/acs.orglett.5b03395

Reference yield: 75.0%

(Z)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylonitrile (37629-77-9) → (Z)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde (1346463-84-0) + (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde (114651-98-8)

Guidance literature:

(Z)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylonitrile; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 - 20 ℃; for 3.5h;

With hydrogenchloride; water; In hexane; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jo2017247

Reference yield: 75.0%

→ (E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)acrylaldehyde (114651-98-8)

Guidance literature:

With dialkylaluminium hydride; In dichloromethane; cyclohexane; at -78 - 20 ℃; for 3.5h;

upstream raw materials:

2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-(E)-propenol

(E)-2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-acrylic acid methyl ester

3,4-dimethoxyphenylacetonitrile

4-methoxy-benzaldehyde

Downstream raw materials:

2-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1,6,7,8,9,9a-hexahydro-4H-quinolizin-4-one

7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienamide

isojulandine

7-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-(E)-5,7-octadienylamine