3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Base Information

Chemical Name:3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide
CAS No.:1344998-45-3
Molecular Formula:BrH*C₂₄H₂₆ClN₃O₃S
Molecular Weight:552.92
Hs Code.:

Synonyms:3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Suppliers and Price of 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

There total 10 articles about 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344995-70-5
1-{[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]methyl}-3-azetidinecarboxylic acid

: 1344998-45-3
3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Guidance literature:: With hydrogen bromide; In tetrahydrofuran; water; acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1344998-45-3
3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -65 °C

2.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C

2.2: 2 h / -10 - 20 °C

2.3: 0.17 h / 0 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 130 °C / Sealed vial; Microwave irradiation

6.1: sodium acetate; acetic acid / methanol / 0.17 h / 20 °C

6.2: 2 h

7.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

7.2: pH ~ 2

7.3: 20 °C / pH ~ 10

8.1: hydrogen bromide / acetonitrile; water; tetrahydrofuran / 0.5 h / 20 °C

With hydrogenchloride; potassium phosphate; n-butyllithium; water; hydrogen bromide; isopropylmagnesium bromide; potassium acetate; sodium acetate; acetic acid; diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; hexane; water; N,N-dimethyl-formamide; acetonitrile; 5.1: Suzuki Coupling;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1344998-45-3
3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 3 h / 75 °C

1.2: Cooling with ice

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 130 °C / Sealed vial; Microwave irradiation

4.1: sodium acetate; acetic acid / methanol / 0.17 h / 20 °C

4.2: 2 h

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

5.2: pH ~ 2

5.3: 20 °C / pH ~ 10

6.1: hydrogen bromide / acetonitrile; water; tetrahydrofuran / 0.5 h / 20 °C

With potassium phosphate; tert.-butylnitrite; water; hydrogen bromide; sodium acetate; acetic acid; sodium hydroxide; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki Coupling;