7-Methyl-1H-pyrrolo[3,2-B]pyridine

Base Information

Chemical Name:7-Methyl-1H-pyrrolo[3,2-B]pyridine
CAS No.:357263-42-4
Molecular Formula:C8H8 N2
Molecular Weight:132.165
Hs Code.:2933990090
European Community (EC) Number:881-641-0
Nikkaji Number:J1.761.277H
Mol file:357263-42-4.mol

Synonyms:7-METHYL-1H-PYRROLO[3,2-B]PYRIDINE;357263-42-4;7-Methyl-4-azaindole;1H-Pyrrolo[3,2-b]pyridine, 7-methyl-;1H-PYRROLO[3,2-B]PYRIDINE,7-METHYL-(9CI);SCHEMBL1473042;HMXZIJABHDJYQQ-UHFFFAOYSA-N;AMY10001;MFCD11845514;7-methyl-4H-pyrrolo[3,2-b]pyridine;AKOS006222552;PB26696;AS-39060;CS-0050001;FT-0718683;EN300-35800;Z381783646;1935221-82-1

Suppliers and Price of 7-Methyl-1H-pyrrolo[3,2-B]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Methyl-1H-pyrrolo[3,2-b]pyridine
5g
$ 2420.00

Matrix Scientific
7-Methyl-4-azaindole 95+%
1g
$ 1420.00

Labseeker
7-methyl-1H-pyrrolo[3,2-b]pyridine 95
10g
$ 2383.00

Crysdot
7-Methyl-1H-pyrrolo[3,2-c]pyridine 95+%
5g
$ 2032.00

Crysdot
7-Methyl-1H-pyrrolo[3,2-c]pyridine 95+%
1g
$ 579.00

Chemenu
7-Methyl-4-azaindole 95%+
10g
$ 1439.00

Chemenu
7-Methyl-4-azaindole 95%+
1g
$ 346.00

Chemenu
7-Methyl-4-azaindole 95%+
5g
$ 1119.00

Chemcia Scientific
7-Methyl-1H-pyrrolo[3,2-b]pyridine ＞97%
5 G
$ 795.00

American Custom Chemicals Corporation
7-METHYL-1H-PYRROLO[3,2-B]PYRIDINE 95.00%
25G
$ 6818.65

Total 23 raw suppliers

Chemical Property of 7-Methyl-1H-pyrrolo[3,2-B]pyridine

Chemical Property:

Boiling Point:281℃
Flash Point:125℃
PSA：28.68000
Density:1.186
LogP:1.87130
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:132.068748264
Heavy Atom Count:10
Complexity:124

Purity/Quality:

99%, ^*data from raw suppliers

7-Methyl-1H-pyrrolo[3,2-b]pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(=NC=C1)C=CN2
Uses 7-Methyl-1H-pyrrolo[3,2-b]pyridine is used as reagent in organic synthesis including that of 1,4-azaindoles which are used as antimycobacterial agents. It is also used in the preparation of antiviral azaindole derivatives.

Technology Process of 7-Methyl-1H-pyrrolo[3,2-B]pyridine

There total 1 articles about 7-Methyl-1H-pyrrolo[3,2-B]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 357263-42-4
7-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid

2: bromine; sodium nitrite; hydrogen bromide / water / 2 h / 0 - 15 °C

3: potassium carbonate / N,N-dimethyl-formamide / 95 °C

4: hydrogenchloride / water; acetonitrile / 2 h / Reflux

5: palladium 10% on activated carbon; hydrogen / water; ethanol / 30 h / 20 °C / 37503.8 Torr

With hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; bromine; nitric acid; potassium carbonate; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1515/hc-2017-0180

Reference yield: 94.0%

: 357263-42-4
7-methyl-1H-pyrrolo[3,2-b]pyridine

: 1190312-40-3
3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: With N-iodo-succinimide; In tetrahydrofuran; for 2h;

Reference yield:

: 357263-42-4
7-methyl-1H-pyrrolo[3,2-b]pyridine

: 1615714-14-1
1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 4 h / Inert atmosphere

3.1: triethylamine / toluene / 0.17 h / Inert atmosphere

3.2: 16 h / 50 °C / Inert atmosphere

4.1: sodium hydroxide / water; ethanol / 5 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm500571f