1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

Base Information

Chemical Name:1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol
CAS No.:1579960-79-4
Molecular Formula:C₂₈H₃₃BrN₂O₄
Molecular Weight:541.485
Hs Code.:

Synonyms:1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

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Chemical Property of 1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

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Technology Process of 1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

There total 5 articles about 1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1159689-74-3
C₁₁H₁₃BrO₃

: 96221-84-0
1-(2-(benzyloxy)phenyl)piperazine

: 1579960-79-4
1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

Guidance literature:: With ethanol; for 8h; Reflux;
DOI:10.1016/j.bmcl.2014.01.070

Reference yield:

: 34743-88-9
2-(4-bromophenoxy)ethanol

: 1579960-79-4
1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ethanol / 8 h / Reflux

With ethanol; sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2014.01.070

Reference yield:

: 106-41-2
4-bromo-phenol

: 1579960-79-4
1-(4-(2-(benzyloxy)phenyl)piperazin-1-yl)-3-(2-(4-bromophenoxy)ethoxy)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 24 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 10 h / Inert atmosphere; Reflux

3.1: ethanol / 8 h / Reflux

With ethanol; sodium hydride; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2014.01.070