4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone

Base Information

• Chemical Name: 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone
• CAS No.: 1256603-88-9
• Molecular Formula: C₃₀H₃₈O₇
• Molecular Weight: 510.628
• Mol file: 1256603-88-9.mol

Synonyms:4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone

Chemical Property of 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone

There total 3 articles about 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-methoxy-benzaldehyde (123-11-5) + 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone (328946-43-6) → 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone (1256603-88-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.cclet.2010.06.037

Reference yield:

trans-geranyl bromide (6138-90-5) → 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone (1256603-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / Reflux

2: potassium carbonate / acetone / Reflux

3: potassium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

With potassium carbonate; potassium hydroxide; In ethanol; water; acetone;

DOI:10.1016/j.cclet.2010.06.037

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 4',6'-bis[(methoxy)methoxy]-2'-hydroxy-4-methoxy-3'-(1''-geranyl)chalcone (1256603-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / Reflux

2: potassium carbonate / acetone / Reflux

3: potassium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

With potassium carbonate; potassium hydroxide; In ethanol; water; acetone;

DOI:10.1016/j.cclet.2010.06.037

upstream raw materials:

trans-geranyl bromide

2,4,6-trihydroxyacetophenone

4-methoxy-benzaldehyde

1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone

Downstream raw materials:

5,7-dihydroxy-4'-methoxy-8-(1''-geranyl)flavanone

5,7-dihydroxy-4'-methoxy-6-(1''-geranyl)flavanone

5,7-bis[(methoxy)methoxy]-4'-methoxy-8-(1''-geranyl)flavanone

2',4',6'-trihydroxy-4-methoxy-3'-(1''-geranyl)chalcone