1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose

Base Information

• Chemical Name: 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose
• CAS No.: 161821-79-0
• Molecular Formula: C₁₇H₂₃O₉P
• Molecular Weight: 402.338
• Mol file: 161821-79-0.mol

Synonyms:1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose

Chemical Property of 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose

There total 4 articles about 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose (6698-46-0) + methyl phosphite (96-36-6,868-85-9) → 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose (161821-79-0)

Guidance literature:

With triethylamine; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85564-2

Reference yield:

benzoyl chloride (98-88-4) → 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose (161821-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / pyridine / 1 h / 0 °C

2: 87 percent / EDC, Cl₂CHCOOH / dimethylsulfoxide; benzene / 3 h / Ambient temperature

3: 95 percent / NEt₃ / 4 h / Ambient temperature

With dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In pyridine; dimethyl sulfoxide; benzene;

DOI:10.1016/S0040-4020(01)85564-2

Reference yield:

1,2-O-isopropylidene-α-D-xylose (20031-21-4) → 1,2-isopropylidene-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose (161821-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / pyridine / 1 h / 0 °C

2: 87 percent / EDC, Cl₂CHCOOH / dimethylsulfoxide; benzene / 3 h / Ambient temperature

3: 95 percent / NEt₃ / 4 h / Ambient temperature

With dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In pyridine; dimethyl sulfoxide; benzene;

DOI:10.1016/S0040-4020(01)85564-2

upstream raw materials:

5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose

methyl phosphite

benzoyl chloride

1,2-O-isopropylidene-α-D-xylose

Downstream raw materials:

1,2-isopropylidene-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose