2 (4-chlorophenyl)-pyrazine

Base Information

Chemical Name:2 (4-chlorophenyl)-pyrazine
CAS No.:108030-79-1
Molecular Formula:C₁₀H₇ClN₂
Molecular Weight:190.632
Hs Code.:

Synonyms:2 (4-chlorophenyl)-pyrazine

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Chemical Property of 2 (4-chlorophenyl)-pyrazine

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Technology Process of 2 (4-chlorophenyl)-pyrazine

There total 10 articles about 2 (4-chlorophenyl)-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 14508-49-7
2-chloropyrazin

: 1679-18-1
4-Chlorophenylboronic acid

: 108030-79-1
2 (4-chlorophenyl)-pyrazine

Guidance literature:: 2-chloropyrazin; 4-Chlorophenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 95 ℃; for 0.166667h; Inert atmosphere;

With potassium fluoride dihydrate; In water; toluene; at 95 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.6b01190

Reference yield: 93.0%

: 17151-48-3
tributyl(4-chlorophenyl)stannane

: 107697-83-6
2-(phenylsulfanyl)pyrazine

: 108030-79-1
2 (4-chlorophenyl)-pyrazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; at 50 ℃; for 21h;
DOI:10.1021/ol0273497

Reference yield: 92.0%

: 17151-48-3
tributyl(4-chlorophenyl)stannane

: 21948-70-9
2-(methylthio)pyrazine

: 108030-79-1
2 (4-chlorophenyl)-pyrazine

Guidance literature:: With trans benzyl(chloro)bis(triphenylphosphine)palladium(II); copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; at 50 ℃;
DOI:10.1021/ol0273497