C₃₂H₂₇BrNO₉P

Base Information

• Chemical Name: C₃₂H₂₇BrNO₉P
• CAS No.: 945594-73-0
• Molecular Formula: C₃₂H₂₇BrNO₉P
• Molecular Weight: 680.445
• Mol file: 945594-73-0.mol

Synonyms:C₃₂H₂₇BrNO₉P

Chemical Property of C₃₂H₂₇BrNO₉P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₇BrNO₉P

There total 6 articles about C₃₂H₂₇BrNO₉P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-benzodioxole-5-acetic acid (2861-28-1) → C32H27BrNO9P (945594-73-0)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride / Heating

2: pyridine / CH₂Cl₂ / 20 °C

3: 59 percent / concentrated HCl / acetic acid / 20 °C

4: 83 percent / H₂ / Pd/C / methanol / 20 °C

5: 99 percent / 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 65 °C

6: KHMDS; HMPA / tetrahydrofuran / -78 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; 4 A molecular sieve; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; 3: Pomeranz-Fritsch-type cyclisation;

DOI:10.1039/b706087d

Reference yield:

3,4-methylenedioxyphenylacetyl chloride (6845-81-4) → C32H27BrNO9P (945594-73-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: 59 percent / concentrated HCl / acetic acid / 20 °C

3: 83 percent / H₂ / Pd/C / methanol / 20 °C

4: 99 percent / 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 65 °C

5: KHMDS; HMPA / tetrahydrofuran / -78 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; 4 A molecular sieve; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; 2: Pomeranz-Fritsch-type cyclisation;

DOI:10.1039/b706087d

Reference yield:

2-Benzo[1,3]dioxol-5-yl-N-(2,2-dimethoxy-ethyl)-acetamide (344338-21-2) → C32H27BrNO9P (945594-73-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / concentrated HCl / acetic acid / 20 °C

2: 83 percent / H₂ / Pd/C / methanol / 20 °C

3: 99 percent / 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 65 °C

4: KHMDS; HMPA / tetrahydrofuran / -78 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; 4 A molecular sieve; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; 1,2-dichloro-ethane; 1: Pomeranz-Fritsch-type cyclisation;

DOI:10.1039/b706087d

upstream raw materials:

C₂₀H₁₈BrNO₆

chlorophosphoric acid diphenyl ester

1,3-benzodioxole-5-acetic acid

3,4-methylenedioxyphenylacetyl chloride

Downstream raw materials:

(6-bromo-2,3-dimethoxy-phenyl)-(5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-methanone

(5,6-dihydro-1,3-dioxa-7-aza-cyclohepta[f]inden-7-yl)-(2,3-dimethoxy-phenyl)-methanone