1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
CAS No.:1375158-57-8
Molecular Formula:C₂₄H₂₂N₄O
Molecular Weight:382.465
Hs Code.:

Synonyms:1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

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Technology Process of 1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

There total 5 articles about 1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.7%

: 3731-52-0
3-Aminomethylpyridine

: 959509-80-9
1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylic acid

: 1375158-57-8
1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1007/s00044-012-0072-4

Reference yield:

: 122-00-9
para-methylacetophenone

: 1375158-57-8
1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol

1.2: Acidic conditions

2.1: hydrazine hydrate; acetic acid / 0.67 h / Reflux

3.1: potassium carbonate / acetonitrile / 8 h / Reflux

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 70 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; lithium hydroxide monohydrate; sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1.1: |Claisen Condensation;
DOI:10.1007/s00044-012-0072-4

Reference yield:

: 39757-29-4
methyl 2,4-dioxo-4-p-tolylbutanoate

: 1375158-57-8
1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate; acetic acid / 0.67 h / Reflux

2: potassium carbonate / acetonitrile / 8 h / Reflux

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 70 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; lithium hydroxide monohydrate; potassium carbonate; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1007/s00044-012-0072-4