(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

Base Information

Chemical Name:(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester
CAS No.:197971-39-4
Molecular Formula:C₁₆H₁₄NO₅P
Molecular Weight:331.265
Hs Code.:

Synonyms:(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

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Chemical Property of (1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

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Technology Process of (1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

There total 2 articles about (1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33512-26-4
diethyl (phthalimidomethyl)phosphonate

: 197971-39-4
(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1.) TMSBr, 2.) AcOH / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) thionyl chloride / 1.) DMF, -35 deg C, 30 min, 2.) DMF, a) 0 deg C, 1 h, b) RT, 12 h

With thionyl chloride; trimethylsilyl bromide; acetic acid; In dichloromethane;
DOI:10.1021/jm970414b

Reference yield:

: 49594-18-5
(phthalimidomethyl) phosphonic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 197971-39-4
(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

Guidance literature:: With thionyl chloride; Yield given. Multistep reaction; 1.) DMF, -35 deg C, 30 min, 2.) DMF, a) 0 deg C, 1 h, b) RT, 12 h;
DOI:10.1021/jm970414b

Reference yield: 100.0%

: 109-73-9,85404-21-3
N-butylamine

: 197971-39-4
(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid monobenzyl ester

: 197971-44-1
C₂₀H₂₃N₂O₄P

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.) 0 deg C, 10 min, 2.) RT, 1.5 h;
DOI:10.1021/jm970414b