N-benzyl-2-imidazoleacetic acid ethyl ester

Base Information

• Chemical Name: N-benzyl-2-imidazoleacetic acid ethyl ester
• CAS No.: 116211-32-6
• Molecular Formula: C₁₄H₁₆N₂O₂
• Molecular Weight: 244.293
• Mol file: 116211-32-6.mol

Synonyms:N-benzyl-2-imidazoleacetic acid ethyl ester

Chemical Property of N-benzyl-2-imidazoleacetic acid ethyl ester

Chemical Property:

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-imidazoleacetic acid ethyl ester

There total 3 articles about N-benzyl-2-imidazoleacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-benzyl-2-methylimidazole (13750-62-4) + chloroformic acid ethyl ester (541-41-3) → N-benzyl-2-imidazoleacetic acid ethyl ester (116211-32-6)

Guidance literature:

With triethylamine; In acetonitrile; at -253.16 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejic.201900763

Reference yield:

benzyl bromide (100-39-0) → N-benzyl-2-imidazoleacetic acid ethyl ester (116211-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / -0.16 °C / Schlenk technique; Inert atmosphere

1.2: Inert atmosphere; Schlenk technique; Reflux

2.1: triethylamine / acetonitrile / 2 h / -253.16 °C / Schlenk technique; Inert atmosphere

With sodium hydride; triethylamine; In acetonitrile;

DOI:10.1002/ejic.201900763

Reference yield:

→ N-benzyl-2-imidazoleacetic acid ethyl ester (116211-32-6)

Guidance literature:

1-Benzyl-2-methyl-imidazol, Chlorameisensaeure-ethylester, Triethylamin, CH3CN;

DOI:10.1021/jo00890a024

upstream raw materials:

N-benzyl-2-methylimidazole

chloroformic acid ethyl ester

benzyl bromide

Downstream raw materials:

ethyl 2-(1H-imidazol-2-yl)acetate

N-(cyclohexylphenylmethyl)-2-(1H-imidazol-2-yl)acetamide

N-(cyclohexylphenylmethyl)-2-(N-benzylimidazol-2-yl)acetamide