(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

Base Information

Chemical Name:(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide
CAS No.:871236-69-0
Molecular Formula:C₃₅H₄₇NO₄Si
Molecular Weight:573.848
Hs Code.:

Synonyms:(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

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Technology Process of (3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

There total 12 articles about (3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₂O₄Si

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 871236-69-0
(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

Guidance literature:: With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2007.05.033

Reference yield:

: 871237-03-5
(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-4-methyl-7-(trityloxy)hept-5-en-1-ol

: 871236-69-0
(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 1 h

2: NaH₂PO₄*H₂O; NaClO₂; 2-methyl-2-butene / tetrahydrofuran; H₂O / 2 h

3: 0.37 g / Et₃N; 4-(dimethylamino)pyridine; DCC / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Dess-Martin periodane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; 1: Dess-Martin oxidation;
DOI:10.1016/j.tet.2007.05.033

Reference yield:

: C₃₃H₄₂O₃Si

: 871236-69-0
(3S,4S,E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaH₂PO₄*H₂O; NaClO₂; 2-methyl-2-butene / tetrahydrofuran; H₂O / 2 h

2: 0.37 g / Et₃N; 4-(dimethylamino)pyridine; DCC / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2007.05.033