1-Phenylcyclobutanecarbonyl chloride

Base Information

• Chemical Name: 1-Phenylcyclobutanecarbonyl chloride
• CAS No.: 4620-67-1
• Molecular Formula: C11H11 Cl O
• Molecular Weight: 194.661
• Hs Code.: 2916399090
• Mol file: 4620-67-1.mol

Synonyms:1-Phenylcyclobutanecarbonyl chloride

Chemical Property of 1-Phenylcyclobutanecarbonyl chloride

Chemical Property:

• PSA: 17.07000
• LogP: 2.87370
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%Min ^*data from raw suppliers

1-Phenylcyclobutanecarbonyl chloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Phenylcyclobutanecarbonyl chloride

There total 5 articles about 1-Phenylcyclobutanecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

oxalyl dichloride (79-37-8) + 1-(phenyl)cyclobutane-1-carboxylic acid (37828-19-6) → 1-phenylcyclobutane-carbonyl chloride (4620-67-1)

Guidance literature:

In diethyl ether;

DOI:10.1016/0022-328X(89)88078-7

Reference yield:

1-phenylcyclobutanecarbonitrile (14377-68-5) → 1-phenylcyclobutane-carbonyl chloride (4620-67-1)

Guidance literature:

Multistep reaction; (i) KOH, diethylene glycol, (ii) SOCl₂, benzene;

Reference yield:

phenylacetonitrile (140-29-4) → 1-phenylcyclobutane-carbonyl chloride (4620-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: liq. NH₃, NaNH₂

2: KOH / bis-(2-hydroxy-ethyl) ether

3: SOCl₂ / dimethylformamide

With potassium hydroxide; thionyl chloride; ammonia; sodium amide; In N,N-dimethyl-formamide; diethylene glycol;

upstream raw materials:

1-phenylcyclobutanecarbonitrile

oxalyl dichloride

1-(phenyl)cyclobutane-1-carboxylic acid

phenylacetonitrile

Downstream raw materials:

<(1-Phenylcyclobutyl)carbonyl>carbamsaeuremethylester

<(1-Phenylcyclobutyl)carbonyl>carbamsaeureethylester

2-(1-Pyrrolidino)ethyl 1-phenylcyclobutanecarboxylate Hydrochloride

2-(4-methoxyphenyl)-1-phenyl-N-(quinolin-8-yl)cyclobutanecarboxamide

Refernces

• 1、 Trace, Rhonda,Jones, W. M.. "In search of α-eliminations of carbon induced by sixteen electron iron: photolysis and thermolysis of derivatives of phenyl substituted cyclobutanes and cyclopropanes". . p. 103 - 114. Retrieved 2007/10/02.