N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide
CAS No.:231951-13-6
Molecular Formula:C₄₂H₄₀N₆O₇
Molecular Weight:740.816
Hs Code.:

<i>N</i>-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9<i>H</i>-purin-6-yl]-benzamide

Synonyms:N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

There total 5 articles about N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 231951-11-4
N-(9-{[6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-(tert-butyl-dimethyl-silanyloxy)-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl]-methyl}-9H-purin-6-yl)-benzamide

: 231951-13-6
N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/1521-3765(20021202)8:23<5312::AID-CHEM5312>3.0.CO;2-M

Reference yield:

: 239808-67-4
4,4’-dimethoxytrityl trifluoromethanesulfonate

: 231951-13-6
N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / pyridine / 60 °C

2: 87 percent / Bu₄NF / tetrahydrofuran / 20 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1002/1521-3765(20021202)8:23<5312::AID-CHEM5312>3.0.CO;2-M

Reference yield:

: 171486-04-7
N⁶-(benzoyl)-9-(carboxymethyl)adenine

: 231951-13-6
N-[9-({6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-8-hydroxy-2-oxa-bicyclo[3.2.1]oct-5-ylcarbamoyl}-methyl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethy; luronium tetrafluoroborate; (i-Pr)2NEt / dimethylformamide / 20 °C

2: 69 percent / pyridine / 60 °C

3: 87 percent / Bu₄NF / tetrahydrofuran / 20 °C

With pyridine; luronium tetrafluoroborate; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethy; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/1521-3765(20021202)8:23<5312::AID-CHEM5312>3.0.CO;2-M