3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

Base Information

Chemical Name:3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one
CAS No.:1256488-42-2
Molecular Formula:C₂₅H₂₃NO₄
Molecular Weight:401.462
Hs Code.:

Synonyms:3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

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Chemical Property of 3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

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Technology Process of 3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

There total 8 articles about 3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1256488-96-6
2-[5-(2-benzyloxy-pyridin-3-yl)-3-tert-butyl-2-methoxy-phenylethynyl]-benzoic acid methyl ester

: 1256488-42-2
3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

Guidance literature:: gold(III) chloride; In trifluoroacetic acid; at 100 ℃; for 0.5h; Sealed tube; Microwave Irradiation;

Reference yield:

: 52200-49-4
3-bromo-2-(phenylmethoxy)pyridine

: 1256488-42-2
3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; bis(pinacol)diborane / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 26 h / 70 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 115 °C / Sealed tube; Microwave Irradiation

3: sodium methylate / methanol / -78 - 20 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 75 °C

5: gold(III) chloride / trifluoroacetic acid / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

With copper(l) iodide; sodium methylate; potassium acetate; sodium carbonate; triethylamine; bis(pinacol)diborane; gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield:

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 1256488-42-2
3-[3-tert-butyl-4-methoxy-5-(1-oxo-1H-isochromen-3-yl)-phenyl]-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / dichloromethane / 1.5 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 115 °C / Sealed tube; Microwave Irradiation

4: sodium methylate / methanol / -78 - 20 °C

5: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 75 °C

6: gold(III) chloride / trifluoroacetic acid / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

With copper(l) iodide; bromine; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;