tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate

Base Information

• Chemical Name: tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate
• CAS No.: 1356349-83-1
• Molecular Formula: C₂₈H₃₄F₂N₄O₆S
• Molecular Weight: 592.664
• Mol file: 1356349-83-1.mol

Synonyms:tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate

Chemical Property of tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate

There total 9 articles about tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(bromomethyl)-4-fluoro-1-nitrobenzene (82420-35-7) → tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate (1356349-83-1)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile

2: triethylamine / dichloromethane / 0 - 25 °C

3: hydrazine hydrate / Raney Nickel / methanol / 0 - 25 °C

4: pyridine / acetone / 0 - 25 °C

With pyridine; hydrazine hydrate; caesium carbonate; triethylamine; Raney Nickel; In methanol; dichloromethane; acetone; acetonitrile;

Reference yield:

8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride (1356349-58-0) + tert-butyl (2-amino-5-fluorobenzyl)[(2S)-1-cyclopentylpropan-2-yl]carbamate (1356349-81-9) → tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate (1356349-83-1)

Guidance literature:

With pyridine; In acetone; at 0 - 25 ℃;

Reference yield:

5-Fluoro-2-nitrotoluene (446-33-3) → tert-butyl [(2S)-1-cyclopentylpropan-2-yl](5-fluoro-2-{[(8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]amino}benzyl)carbamate (1356349-83-1)

Guidance literature:

Multi-step reaction with 5 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 50 - 80 °C

2: caesium carbonate / acetonitrile

3: triethylamine / dichloromethane / 0 - 25 °C

4: hydrazine hydrate / Raney Nickel / methanol / 0 - 25 °C

5: pyridine / acetone / 0 - 25 °C

With pyridine; N-Bromosuccinimide; hydrazine hydrate; caesium carbonate; triethylamine; dibenzoyl peroxide; Raney Nickel; In methanol; tetrachloromethane; dichloromethane; acetone; acetonitrile;

upstream raw materials:

2-(bromomethyl)-4-fluoro-1-nitrobenzene

8-fluoroquinazoline-2,4(1H,3H)-dione

(2S)-1-cyclopentylpropan-2-amine

5-Fluoro-2-nitrotoluene

Downstream raw materials:

N-[2-({[(2S)-1-cyclopentylpropan-2-yl]amino}methyl)-4-fluorophenyl]-8-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide