diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

Base Information

Chemical Name:diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate
CAS No.:1360803-50-4
Molecular Formula:C₁₇H₂₀O₄
Molecular Weight:288.343
Hs Code.:

Synonyms:diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

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Chemical Property of diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

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Technology Process of diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

There total 9 articles about diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1360803-48-0
1-(iodomethyl)-4-(prop-1-yn-1-yl)benzene

: 105-53-3
diethyl malonate

: 1360803-50-4
diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 275386-60-2
4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene

: 1360803-50-4
diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.1: sodium iodide / acetone / 1 h / 20 °C

7.1: sodium iodide / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; methanol; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 1093190-17-0
tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

: 1360803-50-4
diethyl 2-(4-(prop-1-yn-1-yl)benzyl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: sodium iodide / acetone / 1 h / 20 °C

5.1: sodium iodide / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;